Staphylococcal self-loading helicases couple the staircase mechanism with interdomain high flexibility

Cuncun Qiao, Gianluca Debiasi-Anders, Ignacio Mir-Sanchis. Nucleic Acids Res. 2022.



A novel DNA primase-helicase pair encoded by SCCmec elements

Aleksandra Bebel, Melissa A Walsh, Ignacio Mir-Sanchis, Phoebe A Rice. eLife 2020r. doi: 10.7554/eLife.55478



Target highlights in CASP13: Experimental target structures through the eyes of their authors

Rosalba Lepore et al. Proteins. DOI:



Crystal Structure of an Unusual Single-Stranded DNA-Binding Protein Encoded by Staphylococcal Cassette Chromosome Elements*

Mir-Sanchis I, Pigli YZ, Rice PA. Structure. DOI:

*Cover Page   



Staphylococcal SCCmec elements encode an active MCM-like helicase and thus may be replicative*

Mir-Sanchis I, Roman CA, Misiura A, Pigli YZ, Boyle-Vavra S, Rice PA. Nature structural & molecular biology. 2016; 23(10):891-898.

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* Featured in News and Views. 



Moonlighting bacteriophage proteins derepress staphylococcal pathogenicity islands

Tormo-Más MA, Mir I, Shrestha A, Tallent SM, Campoy S, Lasa I, Barbé J, Novick RP, Christie GE, Penadés JR. Nature. 2010; 465(7299):779-82.

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Pirating conserved phage mechanisms promotes promiscuous staphylococcal pathogenicity island transfer

Bowring J, Neamah MM, Donderis J, Mir-Sanchis I, Alite C, Ciges-Tomas JR, Maiques E, Medmedov I, Marina A, Penades JR. eLife. 2017 Aug 8;6. pii: e26487. doi: 10.7554/eLife.26487.

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Sak and Sak4 recombinases are required for bacteriophage replication in Staphylococcus aureus

Neamah MM*, Mir-Sanchis I*, López-Sanz M, Acosta S, Baquedano I, Haag AF, Marina A, Ayora S, Penadés JR. Nucleic Acids Res. 2017; 45(11):6507-6519.

* Co-first authors.

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Control of Staphylococcus aureus pathogenicity island excision

Mir-Sanchis I, Martínez-Rubio R, Martí M, Chen J, Lasa Í, Novick RP, Tormo-Más MÁ, Penadés JR. Molecular microbiology. 2012; 85(5):833-45.

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Phage dUTPases control transfer of virulence genes by a proto-oncogenic G protein-like mechanism

Tormo-Más MÁ, Donderis J, García-Caballer M, Alt A, Mir-Sanchis I, Marina A, Penadés JR. Molecular cell. 2013; 49(5):947-58.

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Virus Satellites Drive Viral Evolution and Ecology

Frígols B, Quiles-Puchalt N, Mir-Sanchis I, Donderis J, Elena SF, Buckling A, Novick RP, Marina A, Penadés JR. PLoS genetics. 2015; 11(10):e1005609.

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